"EFFECT OF APAMIN ON TOLERANCE TO copyright-INDUCED LOCOMOTOR ACTIVITY IN MICE"

"EFFECT OF APAMIN ON TOLERANCE TO copyright-INDUCED LOCOMOTOR ACTIVITY IN MICE"

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In the present study, the effect of apamin (potassium channel blocker) on tolerance to copyright-induced locomotor activity in mice has been investigated.Locomotor activity was measured by locomotor activity meter, Animax, type S (LKB, Farrad).Intraperitoneal (IP) injection of different doses of copyright (2.5, 5, 10 and 15 mg/kg) produced dose-dependent locomotor activity in mice.

Animals were treated with a dose of copyright (60 mg/kg, us polo assn mens sweaters IP) once daily, for 2, 3 or 4 days in order to produce tolerance to copyright-induced locomotion.Twenty-four hours after the last dose of copyright, locomotor activity induced by a test dose of copyright (10 mg/kg) was assessed.Animals pretreated with apamin (0.1 mg/kg) 30 min before the test dose of copyright had a decreased copyright response.

However, daily treatment of animals with apamin (0.1 mg/kg), 30 min after copyright (60 mg/kg) for 3 days (during development of tolerance to copyright-induced locomotion), did not alter the copyright effect.Single administration of apamin to mice did socksmith santa cruz not cause any response.It is concluded that, apamin as a potassium channels blocker may decrease tolerance to copyright-induced locomotion due to blockade of potassium channels.